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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
小鼠
Bmp10 - bone morphogenetic protein 10
Alias:
b2b2711Clo
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Basic Information
Sequence Homology
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
References Literature
这个基因编码一种分泌性的TGF-beta(转化生长因子-β)超家族蛋白质的配体。这个家族的配体结合各种TGF-beta受体,导致SMAD家族转录因子的招募和激活,从而调控基因表达。编码的前原原蛋白经过蛋白水解加工生成成熟蛋白,该成熟蛋白结合激活素样受体激酶1(ALK1),并在心血管发育中扮演重要角色,包括心肌细胞增殖和心脏大小的调控,动脉导管的闭合,血管生成和心室小梁的形成。这个基因的纯合性敲除小鼠心脏发育受损,并表现出胚胎致死性。[RefSeq,2016年8月提供]
Related ID:
NCBI:12154
ENSEMBL:ENSMUSG00000030046
UNIPROT:Q9R229
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Related Mouse Models
Reference
12154
1
2
5519 bp
47.89
12
7
Bmp10 Genetics information (+)
GRCm39
Sequence Homology
Transcripts & Proteins
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#
Transcript
Length(nt)
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Protein
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* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
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Name
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References Literature
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