Axin1 - axin 1

Enables several functions, including SMAD binding activity; beta-catenin binding activity; and enzyme binding activity. Involved in positive regulation of JNK cascade; positive regulation of protein modification process; and positive regulation of transcription, DNA-templated. Acts upstream of or within several processes, including chordate embryonic development; negative regulation of macromolecule metabolic process; and regulation of protein metabolic process. Located in several cellular components, including cell cortex; cytoplasmic vesicle; and microtubule cytoskeleton. Part of Wnt signalosome and beta-catenin destruction complex. Is expressed in several structures, including alimentary system; forebrain; genitourinary system; hemolymphoid system gland; and retina. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human AXIN1 (axin 1). [provided by Alliance of Genome Resources, Apr 2022]