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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
小鼠
Artn - artemin
Alias:
neublastin
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Basic Information
Sequence Homology
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
References Literature
这个基因编码一种胶质细胞系衍生神经营养因子(GDNF)亚家族和TGF-β(转化生长因子-β)蛋白质超家族的分泌配体。这个家族的配体与各种TGF-β受体结合,导致SMAD家族转录因子的招募和激活,从而调控基因表达。编码的前原原蛋白在蛋白水解过程中被加工,生成二硫键连接的同源二聚体的各个亚基。这个蛋白通过RET受体和GFR alpha 3核心受体传递信号,并支持许多外周神经元群体和至少一个多巴胺能CNS神经元的生存。缺乏这个基因功能拷贝的小鼠表现出下垂和交感神经系统发育受损。[RefSeq,2016年8月提供]
Related ID:
NCBI:11876
ENSEMBL:ENSMUSG00000028539
UNIPROT:Q9Z0L2
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Related Mouse Models
Reference
11876
11
5
4889 bp
23.73
2
4
Artn Genetics information (-)
GRCm39
Sequence Homology
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* This data comes from NCBI.
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