Birc3 - baculoviral IAP repeat-containing 3

Predicted to enable cysteine-type endopeptidase inhibitor activity involved in apoptotic process and ubiquitin protein ligase activity. Involved in several processes, including necroptotic process; negative regulation of necroptotic process; and negative regulation of reactive oxygen species metabolic process. Acts upstream of or within cellular response to tumor necrosis factor; positive regulation of protein polyubiquitination; and regulation of NIK/NF-kappaB signaling. Predicted to be located in cytosol; membrane raft; and nucleoplasm. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm and nucleus. Is expressed in genitourinary system. Orthologous to human BIRC3 (baculoviral IAP repeat containing 3). [provided by Alliance of Genome Resources, Apr 2022]