Map3k1 - mitogen-activated protein kinase kinase kinase 1

Enables several functions, including JUN kinase kinase kinase activity; protein kinase binding activity; and ubiquitin-protein transferase activity. Involved in several processes, including cellular protein metabolic process; positive regulation of MAPK cascade; and positive regulation of viral transcription. Located in cytoplasm and membrane. Colocalizes with cytoskeleton. Human ortholog(s) of this gene implicated in 46,XY sex reversal 6 and breast cancer. Orthologous to human MAP3K1 (mitogen-activated protein kinase kinase kinase 1). [provided by Alliance of Genome Resources, Apr 2022]