Adam3 - a disintegrin and metallopeptidase domain 3 (cyritestin)

Predicted to enable metalloendopeptidase activity. Involved in fertilization and flagellated sperm motility. Acts upstream of or within binding activity of sperm to zona pellucida; positive regulation of gene expression; and regulation of mRNA processing. Located in several cellular components, including cell surface; membrane raft; and sperm head. Part of protein-containing complex. Human ortholog(s) of this gene implicated in brain glioma and conjunctival squamous cell carcinoma. Orthologous to human ADAM3A (ADAM metallopeptidase domain 3A (pseudogene)). [provided by Alliance of Genome Resources, Apr 2022]