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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
小鼠
Adam17 - a disintegrin and metallopeptidase domain 17
Alias:
Tace
CD156b
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Basic Information
Sequence Homology
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
References Literature
这个基因编码一个整合素和金属蛋白酶(ADAM)家族的成员,该家族在包括细胞信号传导、粘附和迁移等各种生物过程中发挥重要作用的内切蛋白酶。编码的前原蛋白经历蛋白水解加工,生成参与称为外域切割的膜结合蛋白蛋白水解释放过程的成熟酶。缺乏编码的蛋白质的小鼠在子宫内死亡或在出生后一周内无法存活。可选的剪接导致多个转录变异体,它们编码不同的异构体,其中一些可能经历类似的加工过程。[RefSeq,2016年5月提供]
Related ID:
NCBI:11491
ENSEMBL:ENSMUSG00000052593
UNIPROT:Q9Z0F8
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Related Mouse Models
Reference
11491
4
19
50124 bp
93.06
20
13
Adam17 Genetics information (-)
GRCm39
Sequence Homology
Transcripts & Proteins
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* This data comes from NCBI.
Gene Expression
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Name
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