Cdkn1a - cyclin-dependent kinase inhibitor 1A

Predicted to enable several functions, including cyclin binding activity; enzyme binding activity; and protein kinase regulator activity. Involved in several processes, including intestinal epithelial cell maturation; response to corticosterone; and response to hyperoxia. Located in nucleus and perinuclear region of cytoplasm. Biomarker of autosomal dominant polycystic kidney disease; hypertension (multiple); lipoid nephrosis; liver benign neoplasm; and pre-malignant neoplasm. Human ortholog(s) of this gene implicated in several diseases, including lung non-small cell carcinoma; ocular hypertension; oral mucosa leukoplakia; oral squamous cell carcinoma; and primary open angle glaucoma. Orthologous to human CDKN1A (cyclin dependent kinase inhibitor 1A). [provided by Alliance of Genome Resources, Apr 2022]