Cyp27b1 - cytochrome P450, family 27, subfamily b, polypeptide 1

Enables calcidiol 1-monooxygenase activity. Involved in several processes, including negative regulation of bone trabecula formation; positive regulation of parathyroid hormone secretion; and vitamin D catabolic process. Located in mitochondrion. Used to study Wilson disease; acute kidney failure; nephrosis; and vitamin D-dependent rickets type 1A. Human ortholog(s) of this gene implicated in hepatitis B; obesity; rickets; type 1 diabetes mellitus; and vitamin D-dependent rickets type 1A. Orthologous to human CYP27B1 (cytochrome P450 family 27 subfamily B member 1). [provided by Alliance of Genome Resources, Apr 2022]