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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
小鼠
Aco1 - aconitase 1
Alias:
Irp1
Aco-1
Irebp
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Basic Information
Sequence Homology
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
References Literature
这个基因编码一个酸浆酶/IPM异构酶蛋白家族的成员。已发现该编码蛋白具有多种机制上的功能,因此被认为是兼职蛋白。根据细胞质中铁水平的不同,该编码蛋白可以发挥酸浆酶酶或mRNA结合蛋白的功能。当细胞内铁水平较高时,该编码蛋白作为TCA循环中的一种必需酶发挥作用,催化柠檬酸转化为异柠檬酸。当细胞内铁水平较低时,该编码蛋白通过结合参与铁代谢的基因的mRNA的未翻译区中的铁响应元素来调节铁的摄取和利用。该基因的破坏与肺高血压和多血症有关。[由RefSeq,2014年1月提供]
Related ID:
NCBI:11428
ENSEMBL:ENSMUSG00000028405
UNIPROT:P28271
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Related Mouse Models
Reference
11428
2
21
55745 bp
98.13
12
5
Aco1 Genetics information (+)
GRCm39
Sequence Homology
Transcripts & Proteins
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* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
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