Nrg1 - neuregulin 1

Enables receptor tyrosine kinase binding activity. Involved in several processes, including negative regulation of corticosterone secretion; positive regulation of Schwann cell proliferation; and response to progesterone. Located in extracellular space and synapse. Used to study sciatic neuropathy. Biomarker of diabetic neuropathy; median neuropathy; schizophrenia; and visual epilepsy. Human ortholog(s) of this gene implicated in several diseases, including bipolar disorder; cerebral malaria; dementia; middle cerebral artery infarction; and psychotic disorder (multiple). Orthologous to human NRG1 (neuregulin 1). [provided by Alliance of Genome Resources, Apr 2022]