DDX20 - DEAD-box Helicase 20

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which has an ATPase activity and is a component of the survival of motor neurons (SMN) complex. This protein interacts directly with SMN, the spinal muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on RNPs. [provided by RefSeq, Jul 2008] DEAD box蛋白，其特征是保守的motif Asp-Glu-Ala-Asp（DEAD），是假基因RNA解旋酶。它们参与涉及RNA二级结构改变的许多细胞过程，例如翻译启动，核和线粒体剪接，核糖体和剪接体组装。根据其分布模式，该家族的一些成员被认为参与胚胎发育，精子发生，细胞生长和分裂。该基因编码一种DEAD box蛋白，具有ATP酶活性，并是运动神经元（SMN）复合物的组成部分。这种蛋白质直接与脊髓肌肉萎缩基因产物SMN相互作用，并且可能在SMN复合物对RNP的功能中发挥催化作用。[由RefSeq提供，2008年7月]