人类

PTPN21 - Protein Tyrosine Phosphatase Non-receptor Type 21

Alias:
PTPD1
PTPRL10
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Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
这个基因编码的蛋白质是蛋白质酪氨酸磷酸酶(PTP)家族的一员。PTP被认为是调节各种细胞过程的信号分子,包括细胞生长、分化、有丝分裂周期和癌基因转化。这个PTP包含一个N-末端结构域,与细胞骨架相关蛋白质相似,包括band 4.1、ezrin、merlin和radixin。这个PTP被证明特别与BMX/ETK相互作用,BMX是Tec酪氨酸激酶家族的一员,其特征是多模结构,包括PH结构域、SH3结构域和SH2结构域。这个PTP与BMX激酶的相互作用被发现可以增加STAT3的激活,但不增加STAT2激酶的激活。在小鼠中类似基因的研究提示了这个PTP在肝脏再生和精子发生中可能的作用。[由RefSeq,2008年7月提供]

Basic Information

NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
5
19
89230 bp
133.28
57
--
3
5

PTPN21 Genetics information (-)

GRCh38

Sequence Homology

Related Diseases and Mutations

#
Disease
Anatomical Category
Score
Mutations
No data available

Transcripts & Proteins

Table View
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#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
No data available
* This data comes from NCBI.

Gene Expression

Tissue-specific RNA expression

Organ
Abundance
Alphabetical

Cell-specific RNA expression

Organ
Abundance
Alphabetical

Interactions

Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
No data available

Related Mouse Models

Type
Name
MGI
Strain of Origin
Publications
Mutations
No data available

Related Drugs

Name
CAS Number
Status
Phase
Link
No data available

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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