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中文人类
CPSF4 - Cleavage And Polyadenylation Specific Factor 4
Alias:
NAR
NEB1
NEB-1
CPSF30
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流感A型病毒NS1蛋白通过其效应子结构域抑制含poly(A)的核输出。NS1效应子结构域与细胞切割和多腺苷酸化特异性因子4的30kDa亚基功能相互作用，该亚基是细胞pre-mRNAs 3'端加工机制的必备组件。在流感病毒感染的细胞中，NS1蛋白与切割和多腺苷酸化特异性因子4的30kDa亚基物理结合。在体外，NS1蛋白与30kDa蛋白的结合防止了CPSF结合RNA底物，并抑制了宿主pre-mRNAs的3'端切割和多腺苷酸化。因此，NS1蛋白选择性地抑制细胞而非病毒的mRNA的核输出。该基因编码不同异构体的多种可变剪接转录变异体已被描述。[RefSeq，2008年7月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
CPSF4 Genetics information (+)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
