Ankrd1 - ankyrin repeat domain 1 (cardiac muscle)

Enables titin binding activity and transcription corepressor activity. Involved in cellular response to lipopolysaccharide and cellular response to xenobiotic stimulus. Acts upstream of or within protein kinase C signaling; regulation of transcription by RNA polymerase II; and skeletal muscle cell differentiation. Located in I band and nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; heart; male reproductive gland or organ; skeletal musculature; and somite. Human ortholog(s) of this gene implicated in congenital structural myopathy; dilated cardiomyopathy; hypertrophic cardiomyopathy; nemaline myopathy; and spinal muscular atrophy. Orthologous to human ANKRD1 (ankyrin repeat domain 1). [provided by Alliance of Genome Resources, Apr 2022]