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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
人类
TAF6L - TATA-box Binding Protein Associated Factor 6 Like
Alias:
PAF65A
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Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
RNA聚合酶II的转录起始需要超过70种多肽的活动。协调这些活动的蛋白质是转录因子IID(TFIID),它结合核心启动子以正确定位聚合酶,作为转录复合物的其余部分组装的支架,并作为调节信号的通道。TFIID由TATA结合蛋白(TBP)和一组进化保守的蛋白质组成,称为TBP关联因子或TAFs。TAFs可能参与基础转录,作为协同激活因子,在启动子识别中发挥作用,或者修改通用转录因子(GTFs)以促进复合物组装和转录起始。此基因编码一个蛋白质,是PCAF组蛋白乙酰基转移酶复合物的组成部分,并且结构上与一个类组蛋白TAF,TAF6相似。PCAF组蛋白乙酰基转移酶复合物由超过20种多肽组成,其中一些是TAFs,对于肌源转录和分化是必需的。[由RefSeq,2008年7月提供]
Related ID:
NCBI:10629
ENSEMBL:ENSG00000162227
HGNC:17305
UNIPROT:Q9Y6J9
OMIM:602946
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
10629
3
11
15947 bp
67.81
23
--
2
7
TAF6L Genetics information (+)
GRCh38
Sequence Homology
Related Diseases and Mutations
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* This data comes from NCBI.
Gene Expression
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