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中文人类
UNC13B - Unc-13 Homolog B
Alias:
UNC13
MUNC13
Unc13h2
munc13-2
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这个基因在肾脏皮质上皮细胞中表达，并且高血糖会使其上调。编码的蛋白质与大鼠同源物具有高度相似性，并包含3个C2结构域和一个二脂酰甘油结合的C1结构域。高血糖会升高二脂酰甘油的水平，已经证明在转染这个基因的细胞中可以诱导细胞凋亡，从而参与高血糖的肾脏细胞并发症。在其他物种中的研究也表明这个蛋白质在突触囊泡外泌体释放的启动步骤中发挥作用。[由RefSeq，2008年7月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
UNC13B Genetics information (+)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
