Home
Toolbox
Resource
Workflow
Tutorials
Citations
Downloads
Mutation Al-Predictor Flow
Gene-to-Mutation Flow
News & Insights
Genetic Encyclopedia
Frontiers
Industry Insights
Case Studies
About Us
About the Site
Contact Us
Private Policy
User Agreement
COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
Log In
|
Sign Up
中文
人类
TAB1 - TGF-beta Activated Kinase 1 (MAP3K7) Binding Protein 1
Alias:
3'-Tab1
MAP3K7IP1
Create a favorites folder
Cancel
Confirm
Add To Favorites
Select a favorites
Description
New favorites >>
Cancel
Confirm
Favorite
Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
这个基因编码的蛋白质被鉴定为MAP激酶激酶激酶MAP3K7/TAK1的调节物,已知其调节各种细胞内信号通路,如TGFβ、白细胞介素1和WNT-1诱导的信号通路。这个蛋白质与TAK1激酶相互作用并被激活。已经证明这个蛋白质的C端部分足以结合并激活TAK1,而N端的一部分作为TGFβ的主导阴性抑制剂发挥作用,这表明这个蛋白质可能作为TGFβ受体和TAK1之间的媒介发挥作用。这个蛋白质还可以与有丝分裂原激活的蛋白激酶14(MAPK14/p38alpha)相互作用并被激活,因此代表了除了MAPKK通路之外的替代激活途径,有助于MAPK14对各种刺激的生物学应答。已经报道了一种可产生不同异构体的替代剪接转录变异体。[由RefSeq,2008年7月提供]
Related ID:
NCBI:10454
ENSEMBL:ENSG00000100324
HGNC:18157
UNIPROT:Q15750
OMIM:602615
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
10454
2
11
37353 bp
54.64
21
--
7
28
TAB1 Genetics information (+)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
No data available
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
No data available
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Reset
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
No data available
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
No data available
Related Drugs
Name
CAS Number
Status
Phase
Link
No data available
References Literature
Title
PMID
Journal
Year
IF
No Data Found!
Wechat
Mutation Direct
Sequence
Comparison
Al agent
Tutorials
Back to top