Rfwd3 - ring finger and WD repeat domain 3

Predicted to enable MDM2/MDM4 family protein binding activity; p53 binding activity; and ubiquitin protein ligase activity. Predicted to be involved in several processes, including DNA metabolic process; regulation of cell cycle phase transition; and response to ionizing radiation. Predicted to be located in nucleoplasm and site of DNA damage. Predicted to colocalize with site of double-strand break. Human ortholog(s) of this gene implicated in Fanconi anemia. Orthologous to human RFWD3 (ring finger and WD repeat domain 3). [provided by Alliance of Genome Resources, Apr 2022]