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中文人类
CDKN1B - Cyclin Dependent Kinase Inhibitor 1B
Alias:
KIP1
MEN4
CDKN4
MEN1B
P27KIP1
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这个基因编码一个细胞周期蛋白依赖的激酶抑制剂，它与CDK抑制剂CDKN1A/p21有有限的相似性。编码的蛋白质结合并防止细胞周期蛋白E-CDK2或细胞周期蛋白D-CDK4复合物的激活，从而控制G1期的细胞周期进程。这个蛋白质的降解是由其CDK依赖的磷酸化和SCF复合物随后的泛素化触发的，这是细胞从静止状态过渡到增殖状态所必需的。这个基因的突变与多发性内分泌肿瘤4型（MEN4）有关。[由RefSeq，2014年4月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
CDKN1B Genetics information (+)
GRCh38
Sequence Homology
Related Diseases and Mutations
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Mutations
Transcripts & Proteins
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Transcript
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CDS(bp)
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* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
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Alphabetical
Cell-specific RNA expression
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References Literature
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