Xrcc3 - X-ray repair cross complementing 3

Predicted to enable ATP binding activity and ATP-dependent activity, acting on DNA. Predicted to contribute to crossover junction endodeoxyribonuclease activity and four-way junction DNA binding activity. Involved in response to organic substance. Predicted to be located in several cellular components, including mitochondrion; nucleoplasm; and perinuclear region of cytoplasm. Predicted to be part of Rad51C-XRCC3 complex. Predicted to be active in replication fork. Human ortholog(s) of this gene implicated in breast cancer; familial melanoma; and pancreatic cancer. Orthologous to human XRCC3 (X-ray repair cross complementing 3). [provided by Alliance of Genome Resources, Apr 2022]