人类

PTPRU - Protein Tyrosine Phosphatase Receptor Type U

Alias:
FMI
PTP
PCP-2
PTP-J
PTPRO
PTPU2
PTP-PI
PTP-RO
PTPPSI
hPTP-J
R-PTP-U
R-PTP-PSI
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Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
这个基因编码的蛋白质是蛋白酪氨酸磷酸酶(PTP)家族的一员。PTP被已知为信号分子,可以调节各种细胞过程,包括细胞生长、分化、有丝分裂周期和致癌转化。这个PTP有一个外在区域、一个单个跨膜区域和两个串联的内在催化域,因此代表一种受体型PTP。外在区域包含一个meprin-A5抗原-PTP(MAM)域、Ig样和纤维连接素III样重复。这个PTP被认为在细胞-细胞识别和粘附中发挥作用。对小鼠中类似基因的研究表明,这个PTP在早期神经发育中发挥作用。这个基因的表达在Jurkat T淋巴瘤细胞中被报告为由肉豆蔻酸甲酯(PMA)或钙离子载体调节。已报告了可变剪接转录变体。[由RefSeq提供,2010年8月]

Basic Information

NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
4
30
90279 bp
162.42
62
--
7
14

PTPRU Genetics information (+)

GRCh38

Sequence Homology

Related Diseases and Mutations

#
Disease
Anatomical Category
Score
Mutations
No data available

Transcripts & Proteins

Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
No data available
* This data comes from NCBI.

Gene Expression

Tissue-specific RNA expression

Organ
Abundance
Alphabetical

Cell-specific RNA expression

Organ
Abundance
Alphabetical

Interactions

Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
No data available

Related Mouse Models

Type
Name
MGI
Strain of Origin
Publications
Mutations
No data available

Related Drugs

Name
CAS Number
Status
Phase
Link
No data available

References Literature

Title
PMID
Journal
Year
IF
No Data Found!
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Comparison
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