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中文人类
HUWE1 - HECT, UBA And WWE Domain Containing E3 Ubiquitin Protein Ligase 1
Alias:
MULE
Ib772
LASU1
MRXST
UREB1
HECTH9
URE-B1
ARF-BP1
HSPC272
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这个基因编码一个含有C端HECT(E6AP型E3泛素蛋白连接酶)结构域的蛋白质，作为E3泛素连接酶发挥作用。编码的蛋白质对于抗凋亡蛋白Mcl1(髓样细胞白血病序列1(BCL2相关))的泛素化和后续降解是必需的。该蛋白质还可以泛素化p53肿瘤抑制子、核心组蛋白和DNA聚合酶β。这个基因的突变与Turner型X连锁综合征性认知残疾有关。[RefSeq,2013年8月提供]
Basic Information
NCBI
Transcripts
Exons
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MW (kDa)
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HUWE1 Genetics information (-)
GRCh38
Sequence Homology
Related Diseases and Mutations
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Transcripts & Proteins
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Transcript
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* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
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Cell-specific RNA expression
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References Literature
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