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COL4A5 c.1390G>A
ALS1
DMD c.1332-11868C>G
TP53
肌萎缩侧索硬化症1型
USH2A c.8559-2A>G
囊性纤维化
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中文
人类
IL18BP - Interleukin 18 Binding Protein
Alias:
FVH
IL18BPa
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Description
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Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
这个基因编码的蛋白质作为促炎细胞因子IL18的抑制剂发挥作用。它结合IL18,防止IL18与其受体结合,从而抑制IL18诱导的IFN-γ产生,导致T辅助1型免疫反应减少。这个蛋白质在单核细胞中组成型表达和分泌。在克罗恩病患者的肠道组织中,这个蛋白质的水平升高。这个基因有不同的剪接转录变异体,编码不同的异构体。[RefSeq,2011年2月提供]
Related ID:
NCBI:10068
ENSEMBL:ENSG00000137496
HGNC:5987
UNIPROT:O95998
OMIM:604113
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
10068
18
6
9292 bp
21.10
117
1
8
11
IL18BP Genetics information (+)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
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Transcripts & Proteins
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Protein
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* This data comes from NCBI.
Gene Expression
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