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中文人类
NR1H3 - Nuclear Receptor Subfamily 1 Group H Member 3
Alias:
LXRA
LXR-a
RLD-1
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这个基因编码的蛋白质属于核受体超家族的NR1亚家族。NR1家族成员是巨噬细胞功能的关键调节者，控制与脂质稳态和炎症有关的转录程序。这个蛋白质在包括肝脏、肾脏和肠道在内的内脏器官中高度表达。它与类维生素A X受体（RXR）形成异源二聚体，并调节含有类维生素反应元素的目标基因的表达。缺乏这个基因的小鼠研究提示，它可能在胆固醇稳态调节中扮演重要角色。已经发现这个基因有不同的剪接转录变异体，编码不同的异构体。[RefSeq，2011年10月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
NR1H3 Genetics information (+)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
