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中文人类
MICA - MHC Class I Polypeptide-related Sequence A
Alias:
MIC-A
PERB11.1
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这个基因编码高度多态性的主要组织相容性复合体I类链相关蛋白A。虽然与典型的I类分子不同，但其蛋白产物在细胞表面上表达，但不与β2-微球蛋白结合。它是NKG2D型II整膜蛋白受体的配体。该蛋白作为应激诱导的抗原，被肠道上皮γδ T细胞广泛识别。这个基因的变异与银屑病1和银屑病关节炎的易感性有关，MICA相关抗体和配体的脱落与从意义未明的单克隆丙种球蛋白病发展到多发性骨髓瘤的进展有关。这个基因的可变剪接产生多个转录变异体。[RefSeq，2014年1月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
MICA Genetics information (+)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
