Fbxw7 - F-box and WD repeat domain containing 7

Predicted to enable several functions, including cyclin binding activity; phosphothreonine residue binding activity; and ubiquitin ligase-substrate adaptor activity. Predicted to be involved in several processes, including cellular protein metabolic process; positive regulation of cellular protein metabolic process; and positive regulation of intracellular signal transduction. Predicted to act upstream of or within several processes, including negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding activity; protein destabilization; and vasculogenesis. Predicted to be located in several cellular components, including Golgi apparatus; nuclear lumen; and perinuclear region of cytoplasm. Predicted to be part of Parkin-FBXW7-Cul1 ubiquitin ligase complex and SCF ubiquitin ligase complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human FBXW7 (F-box and WD repeat domain containing 7). [provided by Alliance of Genome Resources, Apr 2022]