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中文人类
HDAC5 - Histone Deacetylase 5
Alias:
HD5
NY-CO-9
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组蛋白在转录调控、细胞周期进展和发育事件中起关键作用。组蛋白的乙酰化/去乙酰化改变染色体结构并影响转录因子对DNA的访问。这个基因编码的蛋白质属于II类组蛋白去乙酰酶/acuc/aph家族。它具有组蛋白去乙酰酶活性，当与启动子结合时抑制转录。它只与HDAC3家族成员共免疫沉淀，可能形成多蛋白复合物。它还与肌细胞增强子因子-2（MEF2）蛋白相互作用，导致MEF2依赖性基因的抑制。这个基因被认为与结肠癌有关。已经发现这个基因有两个编码不同异型的转录变异体。[由RefSeq，2008年7月提供]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
HDAC5 Genetics information (-)
GRCh38
Sequence Homology
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
Transcripts & Proteins
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Interactions
Acting
Regulation
Detail
Mechanism
Target
Residues
Reference
Score
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
Mutations
Related Drugs
Name
CAS Number
Status
Phase
Link
References Literature
Title
PMID
Journal
Year
IF
