Vertebral, Cardiac, Renal, and Limb Defects Syndrome 3, also known as vcrl3, is related to congenital nad deficiency disorder and vertebral, cardiac, renal, and limb defects syndrome 1. An important gene associated with Vertebral, Cardiac, Renal, and Limb Defects Syndrome 3 is NADSYN1 (NAD Synthetase 1). Affiliated tissues include cortex and heart, and related phenotypes are sacral dimple and bicuspid aortic valve