Variegate Porphyria (VP)

Variegate Porphyria, also known as porphyria variegata, is related to porphyria and photoparoxysmal response 1, and has symptoms including abdominal pain, constipation and vomiting. An important gene associated with Variegate Porphyria is PPOX (Protoporphyrinogen Oxidase), and among its related pathways/superpathways are Metabolism and Hemesynthesis defects and porphyrias. The drugs Afamelanotide and Dermatologic Agents have been mentioned in the context of this disorder. Affiliated tissues include skin and liver, and related phenotypes are abdominal pain and abnormal circulating porphyrin concentration