Tetralogy of Fallot (TOF)

法洛氏四联症(来自ICD-11)

别称:

Ventricular Septal Defect with Pulmonary Stenosis or Atresia, Dextraposition of Aorta, and Hypertrophy of Right Ventricle

Fallot Tetralogy

Tof

Interventricular Septal Defect with Dextroposition of Aorta, Pulmonary Stenosis and Hypertrophy of Right Ventricle

Pulmonary Atresia with Ventricular Septal Defect and Systemic-to-Pulmonary Collateral Arteries [fallot Type]

Subpulmonic Stenosis, Ventricular Septal Defect, Overriding Aorta, and Right Ventricular Hypertrophy

Ventricular Septal Defect with Obstructed Right Ventricular Outflow

Pulmonary Atresia with Ventricular Septal Defect [fallot Type]

Pulmonary Atresia, Ventricular Septal Defect and Mapcas

Interventricular Septal Defect, in Tetralogy of Fallot

Tof - [tetralogy of Fallot]

Tetrad of Fallot

Fallot Disease

Fallot Complex

Fallot Tetrad

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基础信息

疾病表征

基因 & 突变

靶点药物

疾病模型

文献报道

法洛四联症，又称室间隔缺损伴肺动脉狭窄或闭锁、主动脉右旋和右心室肥大，与先天性心脏病、多种类型和室间隔缺损有关。与法洛四联症有关的重要基因是JAG1（Jagged Canonical Notch Ligand 1），其相关通路/超级通路包括神经系统发育、胚胎和诱导多能干细胞和特异性标记物。在该疾病的背景下，已提到的药物有厄贝沙坦和抗高血压药物。相关组织包括心脏和气管，相关表型为异常鼻形态和宫内生长迟缓。

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