Thalassemia

Thalassemia, also known as sickle-cell thalassemia without crisis, is related to beta-thalassemia, dominant inclusion body type and hemoglobin e-beta-thalassemia syndrome, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Thalassemia is MIR144 (MicroRNA 144), and among its related pathways/superpathways are Golgi-to-ER retrograde transport and Binding and Uptake of Ligands by Scavenger Receptors. The drugs Peginterferon alfa-2b and Metformin have been mentioned in the context of this disorder. Affiliated tissues include bone marrow and bone, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance