Severe Cutaneous Adverse Reaction (SJS)

重度皮肤不良反应易感性(来自ICD-11)

别称:

Stevens-Johnson Syndrome

Toxic Epidermal Necrolysis

Susceptibility to Severe Cutaneous Adverse Reaction

Dermatostomatitis, Stevens Johnson Type

Lyell Syndrome

Hypersensitivity Syndrome, Carbamazepine-Induced, Susceptibility to

Stevens-Johnson Syndrome Toxic Epidermal Necrolysis Spectrum

Severe Cutaneous Adverse Reaction, Susceptibility to

Hypersensitivity Syndrome, Carbamazepine-Induced

Toxic Epidermal Necrolysis, Susceptibility to

Stevens-Johnson Syndrome, Susceptibility to

Dermatostomatitis Stevens Johnson Type

Drug-Induced Stevens Johnson Syndrome

Ten - [toxic Epidermal Necrolysis]

Sjs

Ten

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基础信息

疾病表征

基因 & 突变

靶点药物

疾病模型

文献报道

严重的皮肤不良反应，也被称为史蒂文斯-约翰逊综合症，与干燥综合症和干眼症有关。与严重的皮肤不良反应有关的重要基因是HLA-B（主要组织相容性复合物，I类，B），其相关通路/超级通路包括NF-κB信号通路和凋亡和自噬。Lenograstim和Pharmaceutical Solutions已在该疾病的背景下被提及。附属组织包括皮肤和眼睛，相关表型为恶心和呕吐和吞咽困难。

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