Stiff-Person Syndrome (SPS)

Stiff-Person Syndrome, also known as stiff-man syndrome, is related to hyperekplexia 1 and encephalitis, and has symptoms including fever, muscle rigidity and opisthotonus. An important gene associated with Stiff-Person Syndrome is AMPH (Amphiphysin), and among its related pathways/superpathways are Glucose / Energy Metabolism and Neuroscience. The drugs Picropodophyllin and Cytarabine have been mentioned in the context of this disorder. Affiliated tissues include breast and spinal cord, and related phenotypes are hyperreflexia and depression