Semantic Dementia, also known as semantic variant ppa, is related to frontotemporal lobar degeneration with tdp43 inclusions, grn-related and amnestic disorder. An important gene associated with Semantic Dementia is PSEN1 (Presenilin 1), and among its related pathways/superpathways are Signaling by ERBB4 and Neuroscience. The drugs Dopamine and Memantine have been mentioned in the context of this disorder. Affiliated tissues include brain and temporal lobe, and related phenotypes are aphasia and brain atrophy