Sacral Defect with Anterior Meningocele (SDAM)

Sacral Defect with Anterior Meningocele, also known as caudal regression syndrome, is related to anus, imperforate and spondylocostal dysostosis 1, autosomal recessive, and has symptoms including back pain and headache. An important gene associated with Sacral Defect with Anterior Meningocele is VANGL1 (VANGL Planar Cell Polarity Protein 1), and among its related pathways/superpathways are Signal Transduction and Gastrulation. Affiliated tissues include spinal cord and kidney, and related phenotypes are bowel incontinence and decreased muscle mass