Scleredema Adultorum

Scleredema Adultorum, also known as buschke's scleredema, is related to systemic scleroderma and graves disease 1, and has symptoms including skin hardening, exanthema and pruritus. An important gene associated with Scleredema Adultorum is INS (Insulin), and among its related pathways/superpathways are Signal Transduction and Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs). The drugs Histamine and Tranilast have been mentioned in the context of this disorder. Affiliated tissues include skin and lung, and related phenotypes are cellular and immune system