Retinal Perforation, also known as retinal break, is related to macular dystrophy, dominant cystoid and degenerative myopia. An important gene associated with Retinal Perforation is COL2A1 (Collagen Type II Alpha 1 Chain), and among its related pathways/superpathways are ERK Signaling and Signal Transduction. The drugs Midazolam and Fentanyl have been mentioned in the context of this disorder. Affiliated tissues include retina and eye, and related phenotypes are Increased gamma-H2AX phosphorylation and nervous system