Primary Lateral Sclerosis, Juvenile (PLSJ)

Primary Lateral Sclerosis, Juvenile, also known as juvenile primary lateral sclerosis, is related to lateral sclerosis and hereditary spastic paraplegia, and has symptoms including upper motor neuron signs An important gene associated with Primary Lateral Sclerosis, Juvenile is ALS2 (Alsin Rho Guanine Nucleotide Exchange Factor ALS2). Affiliated tissues include spinal cord and brain, and related phenotypes are spasticity and hyperreflexia