Plasminogen Deficiency, Type I, also known as hypoplasminogenemia, is related to peripheral vascular disease and thrombophilia due to activated protein c resistance. An important gene associated with Plasminogen Deficiency, Type I is PLG (Plasminogen), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Translation Insulin regulation of translation. The drugs Ophthalmic Solutions and Plasminogen have been mentioned in the context of this disorder. Affiliated tissues include eye and trachea, and related phenotypes are abnormality of the eye and abnormality of vision