Paget's Disease of Bone 2

Paget's Disease of Bone 2, also known as paget disease of bone-2, is related to paget disease of bone 2, early-onset and neurodegeneration with ataxia, dystonia, and gaze palsy, childhood-onset. An important gene associated with Paget's Disease of Bone 2 is SQSTM1 (Sequestosome 1), and among its related pathways/superpathways are Clock-controlled autophagy in bone metabolism and Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway. Affiliated tissues include bone.