Paget's Disease of Bone (PDB)

Paget's Disease of Bone, also known as osteitis deformans, is related to paget's disease of bone 2 and inclusion body myopathy with early-onset paget disease of bone with or without frontotemporal dementia 2, and has symptoms including back pain, muscle cramp and sciatica. An important gene associated with Paget's Disease of Bone is SQSTM1 (Sequestosome 1), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Neuroscience. The drugs Zoledronic acid and Pamidronic acid have been mentioned in the context of this disorder. Affiliated tissues include bone and spinal cord, and related phenotypes are Increased shRNA abundance (Z-score > 2) and shRNA abundance <= 50%.