Orthostatic Intolerance (OI)

直立耐受不能(来自ICD-11)

别称:

Mitral Valve Prolapse

Neurocirculatory Asthenia

Mitral Valve Prolapse Syndrome

Systolic Click-Murmur Syndrome

Irritable Heart

Cardiovascular Malfunction Arising from Mental Factors

Mitral Valve Prolapse, Familial, X-Linked

Prolapsing Mitral Valve Leaflet Syndrome

Ballooning Posterior Leaflet Syndrome

Mitral Valve Prolapse-Click Syndrome

Posterior Mitral Leaflet Deformity

Myxomatous Mitral Valve Prolapse

Billowing Mitral Valve Leaflet

Floppy Mitral Valve Syndrome

Intolerance, Orthostatic

Mitral Valvular Prolapse

Cardiovascular Neurosis

Mitral Leaflet Syndrome

Ballooning Mitral Valve

Myxomatous Mitral Valve

Systolic Click Syndrome

Flail Mitral Leaflet

Floppy Mitral Valve

Da Costa's Syndrome

Krishaber's Disease

Blue Valve Syndrome

Barlow's Syndrome

Barlow Syndrome

Soldiers Heart

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基础信息

疾病表征

基因 & 突变

靶点药物

疾病模型

文献报道

直立不耐受，又称二尖瓣脱垂，与二尖瓣脱垂1和直立性心动过速综合征有关，症状包括心绞痛、胸痛和水肿。与直立不耐受有关的重要基因是SLC6A2（溶质载体家族6成员2），其相关通路/超级通路包括ACE抑制通路、药理动力学和氨基酸代谢。在该疾病的背景下，已提到的药物有卡比多巴和泼尼松龙。相关组织包括心脏和脊髓，相关表型为直立性心动过速和尿中去甲肾上腺素水平升高。

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