Neuropathy, Hereditary, with Liability to Pressure Palsies (HNPP)

Neuropathy, Hereditary, with Liability to Pressure Palsies, also known as tomaculous neuropathy, is related to charcot-marie-tooth disease, axonal, type 2a1 and charcot-marie-tooth disease type 1g, and has symptoms including neuralgia An important gene associated with Neuropathy, Hereditary, with Liability to Pressure Palsies is PMP22 (Peripheral Myelin Protein 22), and among its related pathways/superpathways are Intracellular trafficking proteins involved in CMT neuropathy and EGR2 and SOX10-mediated initiation of Schwann cell myelination. The drugs Folic acid and Lipoic acid have been mentioned in the context of this disorder. Affiliated tissues include spinal cord and brain, and related phenotypes are peripheral neuropathy and decreased motor nerve conduction velocity