Neuroleptic Malignant Syndrome

Neuroleptic Malignant Syndrome is related to acute kidney failure and malignant hyperthermia. An important gene associated with Neuroleptic Malignant Syndrome is CYP2D6 (Cytochrome P450 Family 2 Subfamily D Member 6), and among its related pathways/superpathways are Sudden infant death syndrome (SIDS) susceptibility pathways and Ca, cAMP and Lipid Signaling. The drugs Creatine and Hydroxymethylglutaryl-CoA Reductase Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include kidney and heart, and related phenotypes are hyperhidrosis and abnormal autonomic nervous system physiology