Metacarpal 4-5 Fusion (MF4)

Metacarpal 4-5 Fusion, also known as syndactyly type 8, is related to syndactyly, type iii and spondyloepimetaphyseal dysplasia, x-linked. An important gene associated with Metacarpal 4-5 Fusion is FGF16 (Fibroblast Growth Factor 16), and among its related pathways/superpathways is FGFR3 mutant receptor activation. Affiliated tissues include bone, and related phenotypes are short 5th metacarpal and 4-5 metacarpal synostosis