Male Reproductive System Disease, also known as disorder of male reproductive system, is related to epididymis disease and bladder disease, and has symptoms including pain in testicle, nipple discharge and perineal pain male. An important gene associated with Male Reproductive System Disease is MIR199A1 (MicroRNA 199a-1), and among its related pathways/superpathways are p53 transcriptional gene network and miRNA role in immune response in sepsis. The drugs Progesterone and Dydrogesterone have been mentioned in the context of this disorder. Affiliated tissues include prostate and bone.