Melancholic Depression, also known as endogenous depression, is related to atypical depressive disorder and bipolar i disorder, and has symptoms including depressed - symptom An important gene associated with Melancholic Depression is OXT (Oxytocin/Neurophysin I Prepropeptide), and among its related pathways/superpathways are Signal Transduction and Class A/1 (Rhodopsin-like receptors). The drugs Sevoflurane and Hydroxocobalamin have been mentioned in the context of this disorder. Affiliated tissues include brain and prefrontal cortex, and related phenotypes are Reduced mammosphere formation and nervous system