Megaloblastic Anemia Due to Dihydrofolate Reductase Deficiency (DHFRD)

Megaloblastic Anemia Due to Dihydrofolate Reductase Deficiency, also known as constitutional megaloblastic anemia with severe neurologic disease, is related to megaloblastic anemia and transcobalamin ii deficiency, and has symptoms including ataxia, icterus and absence seizures. An important gene associated with Megaloblastic Anemia Due to Dihydrofolate Reductase Deficiency is DHFR (Dihydrofolate Reductase). Affiliated tissues include bone marrow and bone, and related phenotypes are increased mean corpuscular volume and decreased csf 5-methyltetrahydrofolate concentration