Laron Syndrome (LARS)

Laron综合征(来自ICD-11)

别称:

Growth Hormone Insensitivity Syndrome

Growth Hormone Receptor Deficiency

Laron-Type Isolated Somatotropin Defect

Laron-Type Dwarfism

Laron Dwarfism

Primary Growth Hormone Resistance

Pituitary Dwarfism Ii

Primary Gh Resistance

Short Stature Due to a Defect in Growth Hormone Receptor or Post-Receptor Pathway

Short Stature Due to Growth Hormone Resistance

Complete Growth Hormone Insensitivity

Primary Growth Hormone Insensitivity

Primary Gh Insensitivity

Gh Receptor Deficiency

Ghis

Laron Type Pituitary Dwarfism I

Growth Hormone Receptor Defect

Laron-Type Pituitary Dwarfism

Laron-Type Short Stature

Severe Gh Insensitivity

Gh-R Deficiency

Lars

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基础信息

疾病表征

基因 & 突变

靶点药物

疾病模型

文献报道

拉龙综合症，又称为生长激素不敏感综合症，与生长激素缺乏和孤立性生长激素缺乏有关。与拉龙综合症有关的重要基因是GHR（生长激素受体），其相关通路/超级通路包括ERK信号通路和GPCR通路。在该疾病的背景下提到了药物Mecasermin和胰岛素。附属组织包括垂体和骨骼，相关表型为延迟的骨骼成熟和异常的面部形状

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